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ea0073oc3.2 | Oral Communications 3: Pituitary and Neuroendocrinology | ECE2021

Antitumor effects of growth hormone-releasing hormone (GHRH) antagonists in ACTH–and GH-secreting pituitary neuroendocrine tumor (PitNETs) cell lines

Gesmundo Iacopo , Fanciulli Alessandro , Alvarez Clara V. , Dieguez Carlos , Zatelli Maria Chiara , Grottoli Silvia , Arvat Emanuela , Castaño Justo P. , Cai Renzhi , Sha Wei , Fuentes-Fayos ño , Luque Raùl M. , Ghigo Ezio , Schally Raùl M. , Granata Riccarda

Pituitary neuroendocrine tumors (PitNETs) are mostly benign lesions originating from the anterior pituitary and represent 10–15% of all the intracranial neoplasms. PitNETs can be classified in non-secretory, clinically non-functioning pituitary adenomas (NFPAs), and secretory, comprising prolactin (PRL), growth hormone (GH) and adrenocoticotropic hormone (ACTH). Surgical resection is the first line treatment for PitNETs, whereas chemotherapy and radiotherapy are preferre...

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Antitumor effects of growth hormone-releasing hormone (GHRH) antagonists in ACTH–and GH-secreting pituitary neuroendocrine tumor (PitNETs) cell lines

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